Mesotherapy is a procedure that uses meso injections of hormones, vitamins, enzymes, and plant extracts to rejuvenate, tone the skin, and remove excess fat. In Hyaluronic mesotherapy, a hyaluronic pen is used instead of the regular traditional injections to perform the treatment. This treatment was developed in 1952 in France by Dr Michel Pistor. Originally used to relieve pain, it has since gained popularity in the United States and other parts of the world to treat various skin ailments in males and females over 18.